pentobarbital will reduce the level or outcome of voriconazole by impacting hepatic enzyme CYP2C9/ten metabolism. Minimal/Importance Unidentified.pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can decrease panobinostat levels by ~70% and bring on the